BRD-A73909368_DACTINOMYCIN_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-A73909368_DACTINOMYCIN_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
AQP1 aquaporin 1 (Colton blood group)
BCHE butyrylcholinesterase
BLNK B-cell linker
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA4 carbonic anhydrase IV
CAV2 caveolin 2
CCNA1 cyclin A1
CD302 CD302 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CHGB chromogranin B
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CYBRD1 cytochrome b reductase 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DENND1B DENN/MADD domain containing 1B
EGFL6 EGF-like-domain, multiple 6
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESRP1 epithelial splicing regulatory protein 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GUSBP3 glucuronidase, beta pseudogene 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSM1 insulinoma-associated 1
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2C integral membrane protein 2C
LAMP3 lysosomal-associated membrane protein 3
LPAR6 lysophosphatidic acid receptor 6
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MFAP2 microfibrillar-associated protein 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NLGN4X neuroligin 4, X-linked
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH17 protocadherin 17
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4A phosphodiesterase 4A, cAMP-specific
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
TDO2 tryptophan 2,3-dioxygenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPBG trophoblast glycoprotein
TYROBP TYRO protein tyrosine kinase binding protein
WFDC1 WAP four-disulfide core domain 1
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ACTN1 actinin, alpha 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BHLHE40 basic helix-loop-helix family, member e40
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CRCT1 cysteine-rich C-terminal 1
CRISP3 cysteine-rich secretory protein 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EED embryonic ectoderm development
EHD1 EH-domain containing 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LPIN1 lipin 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MED6 mediator complex subunit 6
MET MET proto-oncogene, receptor tyrosine kinase
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PTGES prostaglandin E synthase
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEC24A SEC24 family member A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPHK1 sphingosine kinase 1
SPRR3 small proline-rich protein 3
SRSF7 serine/arginine-rich splicing factor 7
SYNJ2 synaptojanin 2
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNPO1 transportin 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF22 zinc finger protein 22