BRD-A72703248_SKF 96365 hydrochloride_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-A72703248_SKF 96365 hydrochloride_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYB5R2 cytochrome b5 reductase 2
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FGFR3 fibroblast growth factor receptor 3
GSTA1 glutathione S-transferase alpha 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
IFI27 interferon, alpha-inducible protein 27
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT81 keratin 81, type II
LIMCH1 LIM and calponin homology domains 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
NDNF neuron-derived neurotrophic factor
NNMT nicotinamide N-methyltransferase
PDGFD platelet derived growth factor D
PLXNA1 plexin A1
PODXL podocalyxin-like
RGCC regulator of cell cycle
RTN1 reticulon 1
SHB Src homology 2 domain containing adaptor protein B
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SRGN serglycin
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHRS2 dehydrogenase/reductase (SDR family) member 2
GAS7 growth arrest-specific 7
HAL histidine ammonia-lyase
HIPK1 homeodomain interacting protein kinase 1
HMGA2 high mobility group AT-hook 2
IGF1 insulin-like growth factor 1 (somatomedin C)
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP3 latent transforming growth factor beta binding protein 3
MAGED1 melanoma antigen family D1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
PRKCB protein kinase C, beta
RFC5 replication factor C (activator 1) 5, 36.5kDa
SCG5 secretogranin V
SRSF6 serine/arginine-rich splicing factor 6
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZMAT3 zinc finger, matrin-type 3
ZWINT ZW10 interacting kinetochore protein