BRD-A72703248_SKF 96365 hydrochloride_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-A72703248_SKF 96365 hydrochloride_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT13 acyl-CoA thioesterase 13
ADAT1 adenosine deaminase, tRNA-specific 1
AKAP13 A kinase (PRKA) anchor protein 13
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BID BH3 interacting domain death agonist
C1ORF115 chromosome 1 open reading frame 115
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMP cathelicidin antimicrobial peptide
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CENPE centromere protein E, 312kDa
CKB creatine kinase, brain
CLDN8 claudin 8
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
DCHS1 dachsous cadherin-related 1
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FLNC filamin C, gamma
FLT1 fms-related tyrosine kinase 1
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
FZD5 frizzled class receptor 5
GAGE3 G antigen 3
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GP2 glycoprotein 2 (zymogen granule membrane)
GSTA1 glutathione S-transferase alpha 1
GTSE1 G-2 and S-phase expressed 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA4 heat shock 70kDa protein 4
INSM1 insulinoma-associated 1
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MATN2 matrilin 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NELL2 NEL-like 2 (chicken)
NES nestin
NPY1R neuropeptide Y receptor Y1
NVL nuclear VCP-like
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
ORC1 origin recognition complex, subunit 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE8B phosphodiesterase 8B
PECAM1 platelet/endothelial cell adhesion molecule 1
PHIP pleckstrin homology domain interacting protein
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAP2B phosphatidic acid phosphatase type 2B
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSRC1 proline/serine-rich coiled-coil 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
RAI14 retinoic acid induced 14
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STS steroid sulfatase (microsomal), isozyme S
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBX2 T-box 2
TBXA2R thromboxane A2 receptor
TESK1 testis-specific kinase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNNT1 troponin T type 1 (skeletal, slow)
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ASCC3 activating signal cointegrator 1 complex subunit 3
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BHLHE40 basic helix-loop-helix family, member e40
BMI1 BMI1 proto-oncogene, polycomb ring finger
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFB complement factor B
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DICER1 dicer 1, ribonuclease type III
DUSP4 dual specificity phosphatase 4
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPN2 epsin 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM2 interferon induced transmembrane protein 2
KAZN kazrin, periplakin interacting protein
KDSR 3-ketodihydrosphingosine reductase
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LTBP3 latent transforming growth factor beta binding protein 3
MAGED1 melanoma antigen family D1
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NNMT nicotinamide N-methyltransferase
NPC2 Niemann-Pick disease, type C2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRDX2 peroxiredoxin 2
PRKCZ protein kinase C, zeta
PTGES prostaglandin E synthase
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RUNX1 runt-related transcription factor 1
S100A2 S100 calcium binding protein A2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
SRPX2 sushi-repeat containing protein, X-linked 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAM1 translocation associated membrane protein 1
TSPAN13 tetraspanin 13
UPK1B uroplakin 1B
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZFP36L2 ZFP36 ring finger protein-like 2