BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ASPN asporin
ATF3 activating transcription factor 3
BCHE butyrylcholinesterase
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CAV2 caveolin 2
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CRIP2 cysteine-rich protein 2
CXADR coxsackie virus and adenovirus receptor
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
EMP1 epithelial membrane protein 1
EMP2 epithelial membrane protein 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FNDC3B fibronectin type III domain containing 3B
FRY furry homolog (Drosophila)
FST follistatin
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IL7R interleukin 7 receptor
INHBA inhibin, beta A
ITFG1 integrin alpha FG-GAP repeat containing 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAMP3 lysosomal-associated membrane protein 3
LEPROT leptin receptor overlapping transcript
LSR lipolysis stimulated lipoprotein receptor
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDLIM3 PDZ and LIM domain 3
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
POSTN periostin, osteoblast specific factor
PTPRO protein tyrosine phosphatase, receptor type, O
RBMS1 RNA binding motif, single stranded interacting protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SORBS2 sorbin and SH3 domain containing 2
TBC1D31 TBC1 domain family, member 31
TF transferrin
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UGDH UDP-glucose 6-dehydrogenase
UGP2 UDP-glucose pyrophosphorylase 2
VWA5A von Willebrand factor A domain containing 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AHCY adenosylhomocysteinase
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATPIF1 ATPase inhibitory factor 1
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CAPNS1 calpain, small subunit 1
CD320 CD320 molecule
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CHERP calcium homeostasis endoplasmic reticulum protein
CIRBP cold inducible RNA binding protein
CLTC clathrin, heavy chain (Hc)
COPB1 coatomer protein complex, subunit beta 1
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ETFB electron-transfer-flavoprotein, beta polypeptide
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FSTL1 follistatin-like 1
GATA2 GATA binding protein 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
KRT81 keratin 81, type II
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MATN2 matrilin 2
MEOX2 mesenchyme homeobox 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MRPL12 mitochondrial ribosomal protein L12
MSMB microseminoprotein, beta-
MZT2B mitotic spindle organizing protein 2B
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRMT1 protein arginine methyltransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB4A RAB4A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPL15 ribosomal protein L15
RPL36 ribosomal protein L36
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SGPL1 sphingosine-1-phosphate lyase 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
STK39 serine threonine kinase 39
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYT1 synaptotagmin I
TBCB tubulin folding cofactor B
TBL1X transducin (beta)-like 1X-linked
TRIM28 tripartite motif containing 28
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXLNA taxilin alpha
TXNL4A thioredoxin-like 4A
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2M ubiquitin-conjugating enzyme E2M
UBE2S ubiquitin-conjugating enzyme E2S
YY1 YY1 transcription factor
ZNF217 zinc finger protein 217