BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
C6ORF62 chromosome 6 open reading frame 62
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL2 chemokine (C-X-C motif) ligand 2
CYB5A cytochrome b5 type A (microsomal)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FOXO3 forkhead box O3
GAREM GRB2 associated, regulator of MAPK1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL6 interleukin 6
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLF9 Kruppel-like factor 9
KRT5 keratin 5, type II
MMP1 matrix metallopeptidase 1
MXI1 MAX interactor 1, dimerization protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PELI1 pellino E3 ubiquitin protein ligase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RRAD Ras-related associated with diabetes
SERINC5 serine incorporator 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFTPA2 surfactant protein A2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TAGLN transgelin
TFF3 trefoil factor 3 (intestinal)
TPSAB1 tryptase alpha/beta 1
TXNIP thioredoxin interacting protein
ZFAND5 zinc finger, AN1-type domain 5
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BASP1 brain abundant, membrane attached signal protein 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAPNS1 calpain, small subunit 1
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CENPA centromere protein A
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FXYD5 FXYD domain containing ion transport regulator 5
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
OXTR oxytocin receptor
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PTTG1 pituitary tumor-transforming 1
RGS2 regulator of G-protein signaling 2
SPDL1 spindle apparatus coiled-coil protein 1
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN4 tetraspanin 4
USP22 ubiquitin specific peptidase 22