BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOLD1 apolipoprotein L domain containing 1
AQP8 aquaporin 8
ARG2 arginase 2
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BEX4 brain expressed, X-linked 4
BMP7 bone morphogenetic protein 7
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CBS cystathionine-beta-synthase
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLCA4 chloride channel accessory 4
DOK5 docking protein 5
DSC2 desmocollin 2
DSG3 desmoglein 3
DSP desmoplakin
F13A1 coagulation factor XIII, A1 polypeptide
FAM110B family with sequence similarity 110, member B
GPM6B glycoprotein M6B
GTPBP2 GTP binding protein 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IGKV4-1 immunoglobulin kappa variable 4-1
MICALL1 MICAL-like 1
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1M metallothionein 1M
MUC2 mucin 2, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RRAGD Ras-related GTP binding D
SCG5 secretogranin V
SERINC5 serine incorporator 5
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZG16 zymogen granule protein 16
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNG1 cyclin G1
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CRYZ crystallin, zeta (quinone reductase)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSH cathepsin H
CXCL6 chemokine (C-X-C motif) ligand 6
DDB2 damage-specific DNA binding protein 2, 48kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GAS1 growth arrest-specific 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGFBP6 insulin-like growth factor binding protein 6
IL1B interleukin 1, beta
IRF8 interferon regulatory factor 8
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOXL1 lysyl oxidase-like 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MEIS1 Meis homeobox 1
MKI67 marker of proliferation Ki-67
NDC80 NDC80 kinetochore complex component
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBK PDZ binding kinase
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKCH protein kinase C, eta
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SCP2 sterol carrier protein 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
VCAN versican
VRK1 vaccinia related kinase 1