BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAN aggrecan
ACTN1 actinin, alpha 1
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
CAPN2 calpain 2, (m/II) large subunit
CD9 CD9 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP57 centrosomal protein 57kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
COL9A3 collagen, type IX, alpha 3
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELANE elastase, neutrophil expressed
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GOLGA8A golgin A8 family, member A
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
ISLR immunoglobulin superfamily containing leucine-rich repeat
JUN jun proto-oncogene
KLK10 kallikrein-related peptidase 10
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LCN2 lipocalin 2
LYZ lysozyme
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NFIL3 nuclear factor, interleukin 3 regulated
PENK proenkephalin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
RGCC regulator of cell cycle
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
THBS4 thrombospondin 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAMDEC1 ADAM-like, decysin 1
AHR aryl hydrocarbon receptor
ATF5 activating transcription factor 5
BCHE butyrylcholinesterase
CCNF cyclin F
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EXT1 exostosin glycosyltransferase 1
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
H2BFS H2B histone family, member S (pseudogene)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BK histone cluster 1, H2bk
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LMO3 LIM domain only 3 (rhombotin-like 2)
MARCKSL1 MARCKS-like 1
METRN meteorin, glial cell differentiation regulator
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BGRL SH3 domain binding glutamate-rich protein like
ST18 suppression of tumorigenicity 18, zinc finger
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TUBA1A tubulin, alpha 1a