BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BDKRB2 bradykinin receptor B2
CAPN2 calpain 2, (m/II) large subunit
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COL9A2 collagen, type IX, alpha 2
CTSB cathepsin B
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DUSP4 dual specificity phosphatase 4
EPAS1 endothelial PAS domain protein 1
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM46A family with sequence similarity 46, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FSCN1 fascin actin-bundling protein 1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
GSTP1 glutathione S-transferase pi 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HYOU1 hypoxia up-regulated 1
IDS iduronate 2-sulfatase
IER5 immediate early response 5
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
LCN2 lipocalin 2
LMO4 LIM domain only 4
LRP10 low density lipoprotein receptor-related protein 10
LTBP1 latent transforming growth factor beta binding protein 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MT1E metallothionein 1E
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PPAP2B phosphatidic acid phosphatase type 2B
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RBMS1 RNA binding motif, single stranded interacting protein 1
REG3A regenerating islet-derived 3 alpha
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TBX3 T-box 3
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
ATF1 activating transcription factor 1
C7 complement component 7
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAND1 cullin-associated and neddylation-dissociated 1
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CD24 CD24 molecule
CD2AP CD2-associated protein
CDK1 cyclin-dependent kinase 1
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CKS2 CDC28 protein kinase regulatory subunit 2
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DEPTOR DEP domain containing MTOR-interacting protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
EFHD1 EF-hand domain family, member D1
EFNB3 ephrin-B3
EGR3 early growth response 3
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
FAM111A family with sequence similarity 111, member A
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUD1 glutamate dehydrogenase 1
GREB1 growth regulation by estrogen in breast cancer 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HOXB2 homeobox B2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MANSC1 MANSC domain containing 1
MAPT microtubule-associated protein tau
MELK maternal embryonic leucine zipper kinase
MPC2 mitochondrial pyruvate carrier 2
MREG melanoregulin
MSH6 mutS homolog 6
MUC1 mucin 1, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
OLFML3 olfactomedin-like 3
PAIP1 poly(A) binding protein interacting protein 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRDX3 peroxiredoxin 3
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSPH phosphoserine phosphatase
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB31 RAB31, member RAS oncogene family
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP4 secreted frizzled-related protein 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1