BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD12 ankyrin repeat domain 12
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
CBR3 carbonyl reductase 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CSTA cystatin A (stefin A)
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBN2 fibrillin 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK6 mitogen-activated protein kinase 6
MAST4 microtubule associated serine/threonine kinase family member 4
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTGES prostaglandin E synthase
PTX3 pentraxin 3, long
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SELE selectin E
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMOX spermine oxidase
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
THBD thrombomodulin
THBS4 thrombospondin 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNPO1 transportin 1
TP63 tumor protein p63
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2B ubiquitin-conjugating enzyme E2B
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
BMP4 bone morphogenetic protein 4
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CD200 CD200 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPE carboxypeptidase E
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DUSP6 dual specificity phosphatase 6
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H4C histone cluster 1, H4c
HMGB3 high mobility group box 3
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIF20A kinesin family member 20A
MYB v-myb avian myeloblastosis viral oncogene homolog
PDZK1IP1 PDZK1 interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PON2 paraoxonase 2
PSPH phosphoserine phosphatase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SALL2 spalt-like transcription factor 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
TUBB tubulin, beta class I
VCAN versican