BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CD69 CD69 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL8 chemokine (C-X-C motif) ligand 8
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IL17RB interleukin 17 receptor B
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
LST1 leukocyte specific transcript 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
SATB2 SATB homeobox 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SPON2 spondin 2, extracellular matrix protein
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TCTA T-cell leukemia translocation altered
TSC22D3 TSC22 domain family, member 3
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ANXA1 annexin A1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DAPK1 death-associated protein kinase 1
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN1 ER lipid raft associated 1
FABP7 fatty acid binding protein 7, brain
FLNB filamin B, beta
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GRB14 growth factor receptor-bound protein 14
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
LAMB1 laminin, beta 1
MAGED1 melanoma antigen family D1
MDFIC MyoD family inhibitor domain containing
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MLEC malectin
MMD monocyte to macrophage differentiation-associated
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G16 phospholipase A2, group XVI
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
PTCH1 patched 1
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
STOM stomatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARBP1 TAR (HIV-1) RNA binding protein 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TNC tenascin C
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
UNC119B unc-119 homolog B (C. elegans)
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18