BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CAST calpastatin
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC2B C-type lectin domain family 2, member B
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
FCGBP Fc fragment of IgG binding protein
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT8 keratin 8, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MUC5B mucin 5B, oligomeric mucus/gel-forming
NUPR1 nuclear protein, transcriptional regulator, 1
RGS16 regulator of G-protein signaling 16
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A2 S100 calcium binding protein A2
SFTPB surfactant protein B
SPINK4 serine peptidase inhibitor, Kazal type 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
XIST X inactive specific transcript (non-protein coding)
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
B3GNT1
CBR3 carbonyl reductase 3
CCNF cyclin F
CTTN cortactin
DUSP22 dual specificity phosphatase 22
HOXA10 homeobox A10
HOXB6 homeobox B6
HOXC6 homeobox C6
KIF20A kinesin family member 20A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LY75 lymphocyte antigen 75
MARCKS myristoylated alanine-rich protein kinase C substrate
MLEC malectin
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
OXTR oxytocin receptor
PCGF2 polycomb group ring finger 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPA3 replication protein A3, 14kDa
SACS sacsin molecular chaperone
SLC25A46 solute carrier family 25, member 46
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNC tenascin C
UBE3C ubiquitin protein ligase E3C
USP22 ubiquitin specific peptidase 22
ZBTB18 zinc finger and BTB domain containing 18