BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-A72180425_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AEBP1 AE binding protein 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BIK BCL2-interacting killer (apoptosis-inducing)
BTG3 BTG family, member 3
C1ORF115 chromosome 1 open reading frame 115
CCL20 chemokine (C-C motif) ligand 20
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CLDN7 claudin 7
CLIC5 chloride intracellular channel 5
CLU clusterin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ESRP1 epithelial splicing regulatory protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP1 fatty acid binding protein 1, liver
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IQGAP1 IQ motif containing GTPase activating protein 1
ITM2A integral membrane protein 2A
JAM2 junctional adhesion molecule 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUP junction plakoglobin
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT23 keratin 23, type I
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MUC2 mucin 2, oligomeric mucus/gel-forming
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML3 olfactomedin-like 3
PADI2 peptidyl arginine deiminase, type II
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLS3 plastin 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RPA2 replication protein A2, 32kDa
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOCS2 suppressor of cytokine signaling 2
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQRDL sulfide quinone reductase-like (yeast)
STC1 stanniocalcin 1
STXBP6 syntaxin binding protein 6 (amisyn)
SULF1 sulfatase 1
TEK TEK tyrosine kinase, endothelial
TFF3 trefoil factor 3 (intestinal)
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TOX thymocyte selection-associated high mobility group box
TP53BP2 tumor protein p53 binding protein 2
TPBG trophoblast glycoprotein
TSPAN7 tetraspanin 7
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36 ZFP36 ring finger protein
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL2L1 BCL2-like 1
BST2 bone marrow stromal cell antigen 2
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLCN3 chloride channel, voltage-sensitive 3
CLTC clathrin, heavy chain (Hc)
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF4E eukaryotic translation initiation factor 4E
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
FXYD2 FXYD domain containing ion transport regulator 2
GPX1 glutathione peroxidase 1
HBD hemoglobin, delta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IPO5 importin 5
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS1 lectin, galactoside-binding, soluble, 1
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MIA melanoma inhibitory activity
MTDH metadherin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRSS23 protease, serine, 23
RAD23B RAD23 homolog B (S. cerevisiae)
RHOA ras homolog family member A
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEC24A SEC24 family member A
SEPT9 septin 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
TARBP1 TAR (HIV-1) RNA binding protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TOP1 topoisomerase (DNA) I
TRAPPC3 trafficking protein particle complex 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
VCAN versican
YME1L1 YME1-like 1 ATPase
ZNF185 zinc finger protein 185 (LIM domain)