BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_VCAP_24.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-A71390734_4-Demethoxydaunorubicin hydrochloride (65)_VCAP_24.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BACE2 beta-site APP-cleaving enzyme 2
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA1 chloride channel accessory 1
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
CYB5R2 cytochrome b5 reductase 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DMXL2 Dmx-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOXO4 forkhead box O4
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
GUSBP3 glucuronidase, beta pseudogene 3
HEBP2 heme binding protein 2
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
LITAF lipopolysaccharide-induced TNF factor
MAN1C1 mannosidase, alpha, class 1C, member 1
MATN2 matrilin 2
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYOF myoferlin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP2 NLR family, pyrin domain containing 2
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OPTN optineurin
PALLD palladin, cytoskeletal associated protein
PDE4DIP phosphodiesterase 4D interacting protein
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCD protein kinase C, delta
PSCA prostate stem cell antigen
QPCT glutaminyl-peptide cyclotransferase
RAB15 RAB15, member RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A10 S100 calcium binding protein A10
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKAP2 src kinase associated phosphoprotein 2
SNN stannin
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP2 signal transducing adaptor family member 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNM synemin, intermediate filament protein
TBX3 T-box 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCL1A T-cell leukemia/lymphoma 1A
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM255A transmembrane protein 255A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TSPAN6 tetraspanin 6
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACAT1 acetyl-CoA acetyltransferase 1
ADGRE5 adhesion G protein-coupled receptor E5
AK4 adenylate kinase 4
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BOP1 block of proliferation 1
BYSL bystin-like
BZW2 basic leucine zipper and W2 domains 2
C14ORF2 chromosome 14 open reading frame 2
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CCNF cyclin F
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CD320 CD320 molecule
CDC20 cell division cycle 20
CENPE centromere protein E, 312kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CTPS1 CTP synthase 1
CXCL9 chemokine (C-X-C motif) ligand 9
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPH2 DPH2 homolog (S. cerevisiae)
EBNA1BP2 EBNA1 binding protein 2
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
FAM216A family with sequence similarity 216, member A
FAR2 fatty acyl CoA reductase 2
FBL fibrillarin
FJX1 four jointed box 1 (Drosophila)
FOLR1 folate receptor 1 (adult)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GLB1L2 galactosidase, beta 1-like 2
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HMG20B high mobility group 20B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KAZN kazrin, periplakin interacting protein
KIAA0020 KIAA0020
KIF20A kinesin family member 20A
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY6E lymphocyte antigen 6 complex, locus E
MINA MYC induced nuclear antigen
MMP9 matrix metallopeptidase 9
MRPL12 mitochondrial ribosomal protein L12
MRPL24 mitochondrial ribosomal protein L24
MRPL3 mitochondrial ribosomal protein L3
MRPS30 mitochondrial ribosomal protein S30
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NHP2 NHP2 ribonucleoprotein
NIT2 nitrilase family, member 2
NLE1 notchless homolog 1 (Drosophila)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
ODC1 ornithine decarboxylase 1
ORC5 origin recognition complex, subunit 5
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCCB propionyl CoA carboxylase, beta polypeptide
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POLD2 polymerase (DNA directed), delta 2, accessory subunit
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRR7 proline rich 7 (synaptic)
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RALGDS ral guanine nucleotide dissociation stimulator
RCC1 regulator of chromosome condensation 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SACS sacsin molecular chaperone
SCARB1 scavenger receptor class B, member 1
SERBP1 SERPINE1 mRNA binding protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMS spermine synthase
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SRM spermidine synthase
STAR steroidogenic acute regulatory protein
TFF3 trefoil factor 3 (intestinal)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMED3 transmembrane emp24 protein transport domain containing 3
TRAP1 TNF receptor-associated protein 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBXN8 UBX domain protein 8
WDR12 WD repeat domain 12
WT1 Wilms tumor 1
ZC3H15 zinc finger CCCH-type containing 15
ZNF593 zinc finger protein 593