BRD-A70155556_NP-001236_MDST8_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A70155556_NP-001236_MDST8_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT1 angiopoietin 1
ARMCX2 armadillo repeat containing, X-linked 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
CA12 carbonic anhydrase XII
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CSRP1 cysteine and glycine-rich protein 1
CTBP2 C-terminal binding protein 2
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
FBXO11 F-box protein 11
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST3H2A histone cluster 3, H2a
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KRT20 keratin 20, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MEOX2 mesenchyme homeobox 2
MPPED2 metallophosphoesterase domain containing 2
NEFH neurofilament, heavy polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NLRP2 NLR family, pyrin domain containing 2
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
PEG10 paternally expressed 10
PLSCR4 phospholipid scramblase 4
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMC1A structural maintenance of chromosomes 1A
SSBP2 single-stranded DNA binding protein 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK10 serine/threonine kinase 10
TAL1 T-cell acute lymphocytic leukemia 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TMSB15A thymosin beta 15a
TSC22D3 TSC22 domain family, member 3
TSPAN6 tetraspanin 6
UBE2J1 ubiquitin-conjugating enzyme E2, J1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
C8ORF4 chromosome 8 open reading frame 4
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL4 chemokine (C-C motif) ligand 4
CD320 CD320 molecule
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM69A family with sequence similarity 69, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HBEGF heparin-binding EGF-like growth factor
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
KDM5D lysine (K)-specific demethylase 5D
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LUM lumican
MBOAT7 membrane bound O-acyltransferase domain containing 7
MME membrane metallo-endopeptidase
NEBL nebulette
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NUP210 nucleoporin 210kDa
OBSL1 obscurin-like 1
OXTR oxytocin receptor
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
PSD3 pleckstrin and Sec7 domain containing 3
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TYMP thymidine phosphorylase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican