BRD-A70155556_NP-001236_MCF7_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-A70155556_NP-001236_MCF7_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
AHNAK AHNAK nucleoprotein
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BLVRA biliverdin reductase A
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CLCA2 chloride channel accessory 2
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DMXL2 Dmx-like 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FXYD3 FXYD domain containing ion transport regulator 3
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
JCHAIN joining chain of multimeric IgA and IgM
JUND jun D proto-oncogene
JUP junction plakoglobin
KDM4B lysine (K)-specific demethylase 4B
KIAA1324 KIAA1324
KRT14 keratin 14, type I
LAMA3 laminin, alpha 3
LDOC1 leucine zipper, down-regulated in cancer 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYPD3 LY6/PLAUR domain containing 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NCF2 neutrophil cytosolic factor 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NPY1R neuropeptide Y receptor Y1
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPOX protoporphyrinogen oxidase
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRSS8 protease, serine, 8
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
RAP1GAP RAP1 GTPase activating protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCTA T-cell leukemia translocation altered
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
WDR13 WD repeat domain 13
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP7 A kinase (PRKA) anchor protein 7
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CEP57 centrosomal protein 57kDa
CHEK2 checkpoint kinase 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EMG1 EMG1 N1-specific pseudouridine methyltransferase
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FAR2 fatty acyl CoA reductase 2
FEN1 flap structure-specific endonuclease 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMDS GDP-mannose 4,6-dehydratase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H4C histone cluster 1, H4c
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITM2A integral membrane protein 2A
LMO4 LIM domain only 4
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MSH6 mutS homolog 6
NCAPD3 non-SMC condensin II complex, subunit D3
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDGFA platelet-derived growth factor alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFN2 profilin 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX4 peroxiredoxin 4
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RANBP1 RAN binding protein 1
RPL39L ribosomal protein L39-like
SEH1L SEH1-like (S. cerevisiae)
SIVA1 SIVA1, apoptosis-inducing factor
SMC4 structural maintenance of chromosomes 4
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
TFAM transcription factor A, mitochondrial
TIPIN TIMELESS interacting protein
TMEM126B transmembrane protein 126B
TMEM38B transmembrane protein 38B
TMX1 thioredoxin-related transmembrane protein 1
TRIP13 thyroid hormone receptor interactor 13
TSPAN3 tetraspanin 3
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1