BRD-A70155556_NP-001236_HEPG2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-A70155556_NP-001236_HEPG2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BEX4 brain expressed, X-linked 4
CCND2 cyclin D2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP6 fatty acid binding protein 6, ileal
FMOD fibromodulin
GAB2 GRB2-associated binding protein 2
HMOX1 heme oxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
KIAA1462 KIAA1462
LAMA4 laminin, alpha 4
LEF1 lymphoid enhancer-binding factor 1
MMP3 matrix metallopeptidase 3
NDRG1 N-myc downstream regulated 1
NFE2 nuclear factor, erythroid 2
P3H2 prolyl 3-hydroxylase 2
PCDH7 protocadherin 7
PPAP2B phosphatidic acid phosphatase type 2B
PPOX protoporphyrinogen oxidase
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SFRP1 secreted frizzled-related protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TCF4 transcription factor 4
TES testin LIM domain protein
TKT transketolase
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG6 adhesion G protein-coupled receptor G6
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BBX bobby sox homolog (Drosophila)
BID BH3 interacting domain death agonist
COCH cochlin
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FOXC1 forkhead box C1
GCH1 GTP cyclohydrolase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSN gelsolin
HAL histidine ammonia-lyase
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP1 insulin-like growth factor binding protein 1
KRT23 keratin 23, type I
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MTCL1 microtubule crosslinking factor 1
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMP22 peripheral myelin protein 22
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100A2 S100 calcium binding protein A2
SERBP1 SERPINE1 mRNA binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SF1 splicing factor 1
SOX9 SRY (sex determining region Y)-box 9
SQRDL sulfide quinone reductase-like (yeast)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF11 serine/arginine-rich splicing factor 11
SRSF6 serine/arginine-rich splicing factor 6
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3