BRD-A70155556_NP-001236_HA1E_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

264 genes differentially expressed following the BRD-A70155556_NP-001236_HA1E_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADCY1 adenylate cyclase 1 (brain)
ADGRG1 adhesion G protein-coupled receptor G1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCL5 chemokine (C-C motif) ligand 5
CDC25B cell division cycle 25B
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLCA2 chloride channel accessory 2
CRABP2 cellular retinoic acid binding protein 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DNM1 dynamin 1
DPP4 dipeptidyl-peptidase 4
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM49A family with sequence similarity 49, member A
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
FXYD6 FXYD domain containing ion transport regulator 6
G6PD glucose-6-phosphate dehydrogenase
GANAB glucosidase, alpha; neutral AB
GAREM GRB2 associated, regulator of MAPK1
GLUL glutamate-ammonia ligase
GUSB glucuronidase, beta
HBP1 HMG-box transcription factor 1
ISCU iron-sulfur cluster assembly enzyme
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2B integral membrane protein 2B
KIAA0430 KIAA0430
KLF11 Kruppel-like factor 11
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
MAGEA3 melanoma antigen family A3
MAN1C1 mannosidase, alpha, class 1C, member 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEB nebulin
NEFL neurofilament, light polypeptide
NPEPL1 aminopeptidase-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB1 nucleobindin 1
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
PAX8 paired box 8
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PLD3 phospholipase D family, member 3
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PPL periplakin
PRKCSH protein kinase C substrate 80K-H
PTPRK protein tyrosine phosphatase, receptor type, K
PYCARD PYD and CARD domain containing
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNF19B ring finger protein 19B
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERINC1 serine incorporator 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOBP sine oculis binding protein homolog (Drosophila)
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SYT1 synaptotagmin I
TGFB1 transforming growth factor, beta 1
TGOLN2 trans-golgi network protein 2
THEMIS2 thymocyte selection associated family member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
VEGFA vascular endothelial growth factor A
YIPF3 Yip1 domain family, member 3

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADM adrenomedullin
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDNF brain-derived neurotrophic factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALB1 calbindin 1, 28kDa
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CELF2 CUGBP, Elav-like family member 2
CFAP20 cilia and flagella associated protein 20
CFLAR CASP8 and FADD-like apoptosis regulator
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLTB clathrin, light chain B
COX11 COX11 cytochrome c oxidase copper chaperone
CSRP2 cysteine and glycine-rich protein 2
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4A3 eukaryotic translation initiation factor 4A3
EMG1 EMG1 N1-specific pseudouridine methyltransferase
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM171A1 family with sequence similarity 171, member A1
FAM216A family with sequence similarity 216, member A
FASTKD1 FAST kinase domains 1
FERMT2 fermitin family member 2
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GLIPR1 GLI pathogenesis-related 1
GTF2A2 general transcription factor IIA, 2, 12kDa
GTPBP4 GTP binding protein 4
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAS2 hyaluronan synthase 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFI27 interferon, alpha-inducible protein 27
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
KLK7 kallikrein-related peptidase 7
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
LRRC59 leucine rich repeat containing 59
MAP2K3 mitogen-activated protein kinase kinase 3
MID1 midline 1
MOK MOK protein kinase
MRPL42 mitochondrial ribosomal protein L42
MRPS7 mitochondrial ribosomal protein S7
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL9 myosin, light chain 9, regulatory
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUP98 nucleoporin 98kDa
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PGK1 phosphoglycerate kinase 1
PHB prohibitin
PLS3 plastin 3
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRSS23 protease, serine, 23
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RBM12 RNA binding motif protein 12
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL26L1 ribosomal protein L26-like 1
RPS5 ribosomal protein S5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFPQ splicing factor proline/glutamine-rich
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPAG4 sperm associated antigen 4
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
TDG thymine-DNA glycosylase
TFRC transferrin receptor
THBS1 thrombospondin 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TRA2B transformer 2 beta homolog (Drosophila)
TSPAN8 tetraspanin 8
TUFT1 tuftelin 1
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2N ubiquitin-conjugating enzyme E2N
UCK2 uridine-cytidine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
WDR12 WD repeat domain 12
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing