BRD-A70155556_NP-001236_A549_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-A70155556_NP-001236_A549_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CERS6 ceramide synthase 6
COG7 component of oligomeric golgi complex 7
CRABP2 cellular retinoic acid binding protein 2
CST1 cystatin SN
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
EHD2 EH-domain containing 2
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GSN gelsolin
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KLF2 Kruppel-like factor 2
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LGMN legumain
LHFPL2 lipoma HMGIC fusion partner-like 2
LYPD3 LY6/PLAUR domain containing 3
MGLL monoglyceride lipase
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPDC1 neural proliferation, differentiation and control, 1
NRIP1 nuclear receptor interacting protein 1
PBX1 pre-B-cell leukemia homeobox 1
PERP PERP, TP53 apoptosis effector
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAB15 RAB15, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RHOB ras homolog family member B
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TCTA T-cell leukemia translocation altered
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNIP1 TNFAIP3 interacting protein 1
TP53I3 tumor protein p53 inducible protein 3
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
TSPO translocator protein (18kDa)
TST thiosulfate sulfurtransferase (rhodanese)
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ALDOB aldolase B, fructose-bisphosphate
BAG2 BCL2-associated athanogene 2
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CD1E CD1e molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP1 fatty acid binding protein 1, liver
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HOXC6 homeobox C6
IGHM immunoglobulin heavy constant mu
NMT2 N-myristoyltransferase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLK1 polo-like kinase 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PSPH phosphoserine phosphatase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
SDC2 syndecan 2
SRSF7 serine/arginine-rich splicing factor 7
TAGLN transgelin
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4