BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADIRF adipogenesis regulatory factor
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CRYAB crystallin, alpha B
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
E2F2 E2F transcription factor 2
FGFBP1 fibroblast growth factor binding protein 1
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MAOB monoamine oxidase B
MAST4 microtubule associated serine/threonine kinase family member 4
MT1M metallothionein 1M
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PELI1 pellino E3 ubiquitin protein ligase 1
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RRAD Ras-related associated with diabetes
SFN stratifin
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TPSAB1 tryptase alpha/beta 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ARHGAP29 Rho GTPase activating protein 29
AURKA aurora kinase A
BTBD3 BTB (POZ) domain containing 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL19 chemokine (C-C motif) ligand 19
CCNB2 cyclin B2
CDC20 cell division cycle 20
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CTSH cathepsin H
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2R coagulation factor II (thrombin) receptor
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HOXA10 homeobox A10
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MLEC malectin
MMD monocyte to macrophage differentiation-associated
NEK2 NIMA-related kinase 2
NPY neuropeptide Y
NT5DC2 5'-nucleotidase domain containing 2
PLIN1 perilipin 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTTG1 pituitary tumor-transforming 1
RBP4 retinol binding protein 4, plasma
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STK39 serine threonine kinase 39
TCTA T-cell leukemia translocation altered
TFF1 trefoil factor 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
VCAN versican