BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

121 genes differentially expressed following the BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOB aldolase B, fructose-bisphosphate
ATF3 activating transcription factor 3
BMP7 bone morphogenetic protein 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDV3 CDV3 homolog (mouse)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
CTTN cortactin
DDIT4 DNA-damage-inducible transcript 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSG3 desmoglein 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
ITM2C integral membrane protein 2C
KRT6B keratin 6B, type II
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PROM1 prominin 1
PTX3 pentraxin 3, long
RHCG Rh family, C glycoprotein
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX13 sorting nexin 13
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CST7 cystatin F (leukocystatin)
CTSG cathepsin G
CTSH cathepsin H
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
G0S2 G0/G1 switch 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB2 homeobox B2
IFI16 interferon, gamma-inducible protein 16
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1B interleukin 1, beta
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MLPH melanophilin
MYOF myoferlin
NCAPG non-SMC condensin I complex, subunit G
NES nestin
NRIP1 nuclear receptor interacting protein 1
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPDEF SAM pointed domain containing ETS transcription factor
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TTK TTK protein kinase
VCAN versican
ZCCHC24 zinc finger, CCHC domain containing 24