BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

176 genes differentially expressed following the BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE40 basic helix-loop-helix family, member e40
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CD44 CD44 molecule (Indian blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC11A C-type lectin domain family 11, member A
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNOT2 CCR4-NOT transcription complex, subunit 2
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
FCMR Fc fragment of IgM receptor
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IQCG IQ motif containing G
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
LCN2 lipocalin 2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NQO2 NAD(P)H dehydrogenase, quinone 2
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RGCC regulator of cell cycle
SATB1 SATB homeobox 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SORBS2 sorbin and SH3 domain containing 2
SPRR3 small proline-rich protein 3
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TMPRSS3 transmembrane protease, serine 3
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
XPOT exportin, tRNA
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANOS1 anosmin 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CD36 CD36 molecule (thrombospondin receptor)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLINT1 clathrin interactor 1
COL21A1 collagen, type XXI, alpha 1
COL4A5 collagen, type IV, alpha 5
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSH cathepsin H
DAPK1 death-associated protein kinase 1
DMD dystrophin
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD6 frizzled class receptor 6
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP5 insulin-like growth factor binding protein 5
IGSF3 immunoglobulin superfamily, member 3
KANK1 KN motif and ankyrin repeat domains 1
KIAA0907 KIAA0907
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC17 leucine rich repeat containing 17
MALL mal, T-cell differentiation protein-like
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLEC malectin
MTSS1 metastasis suppressor 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH10 myosin, heavy chain 10, non-muscle
NAV2 neuron navigator 2
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
PBX1 pre-B-cell leukemia homeobox 1
PNMA2 paraneoplastic Ma antigen 2
PRKCD protein kinase C, delta
PYGB phosphorylase, glycogen; brain
RFTN1 raftlin, lipid raft linker 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STARD7 StAR-related lipid transfer (START) domain containing 7
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TARDBP TAR DNA binding protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TMEM164 transmembrane protein 164
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TNS3 tensin 3
TRIM22 tripartite motif containing 22
TSPAN13 tetraspanin 13
USP22 ubiquitin specific peptidase 22
WEE1 WEE1 G2 checkpoint kinase
ZNF512B zinc finger protein 512B
ZNF587 zinc finger protein 587