BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD10 ankyrin repeat domain 10
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BTG3 BTG family, member 3
CBR3 carbonyl reductase 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP1B charged multivesicular body protein 1B
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5A eukaryotic translation initiation factor 5A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK6 mitogen-activated protein kinase 6
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MT1F metallothionein 1F
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBPC1 myosin binding protein C, slow type
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOVA1 neuro-oncological ventral antigen 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMOX spermine oxidase
SOD2 superoxide dismutase 2, mitochondrial
SPAG9 sperm associated antigen 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THBD thrombomodulin
TMED5 transmembrane emp24 protein transport domain containing 5
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TNPO1 transportin 1
TP63 tumor protein p63
TREM1 triggering receptor expressed on myeloid cells 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2B ubiquitin-conjugating enzyme E2B
UFM1 ubiquitin-fold modifier 1
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANOS1 anosmin 1
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
BCHE butyrylcholinesterase
BMP4 bone morphogenetic protein 4
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNN1 calponin 1, basic, smooth muscle
COL13A1 collagen, type XIII, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRIP2 cysteine-rich protein 2
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FILIP1L filamin A interacting protein 1-like
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H4J histone cluster 1, H4j
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPGDS hematopoietic prostaglandin D synthase
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KIF20A kinesin family member 20A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYRF myelin regulatory factor
NOL11 nucleolar protein 11
PDLIM3 PDZ and LIM domain 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLN phospholamban
RBPMS RNA binding protein with multiple splicing
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
SALL2 spalt-like transcription factor 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VAMP8 vesicle-associated membrane protein 8
VSNL1 visinin-like 1