BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
AKAP9 A kinase (PRKA) anchor protein 9
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BSG basigin (Ok blood group)
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DLG1 discs, large homolog 1 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EVI2A ecotropic viral integration site 2A
FGL2 fibrinogen-like 2
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIF5C kinesin family member 5C
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
LRMP lymphoid-restricted membrane protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NCF1C neutrophil cytosolic factor 1C pseudogene
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG3 paternally expressed 3
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
RABGAP1L RAB GTPase activating protein 1-like
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RGS16 regulator of G-protein signaling 16
RNF13 ring finger protein 13
SEPP1 selenoprotein P, plasma, 1
SERTAD2 SERTA domain containing 2
SLC38A1 solute carrier family 38, member 1
SOBP sine oculis binding protein homolog (Drosophila)
SST somatostatin
STC2 stanniocalcin 2
TF transferrin
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TRA2A transformer 2 alpha homolog (Drosophila)
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZG16 zymogen granule protein 16
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ACTN1 actinin, alpha 1
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
AURKA aurora kinase A
B3GNT1
BAG5 BCL2-associated athanogene 5
BICD2 bicaudal D homolog 2 (Drosophila)
BLVRA biliverdin reductase A
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLG5 discs, large homolog 5 (Drosophila)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EFNB2 ephrin-B2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FXYD2 FXYD domain containing ion transport regulator 2
FZD7 frizzled class receptor 7
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLRX glutaredoxin (thioltransferase)
GPX1 glutathione peroxidase 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB6 homeobox B6
HOXB7 homeobox B7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
KANK2 KN motif and ankyrin repeat domains 2
KIF1BP KIF1 binding protein
KIF2C kinesin family member 2C
LASP1 LIM and SH3 protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPLA1 lysophospholipase I
MAGED1 melanoma antigen family D1
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MGST2 microsomal glutathione S-transferase 2
MSH6 mutS homolog 6
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NISCH nischarin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCGF2 polycomb group ring finger 2
PDZK1 PDZ domain containing 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RAB11A RAB11A, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RBM47 RNA binding motif protein 47
RBPMS RNA binding protein with multiple splicing
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
RRP1B ribosomal RNA processing 1B
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SACS sacsin molecular chaperone
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A4 solute carrier family 16, member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SRP54 signal recognition particle 54kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TNC tenascin C
TRAPPC4 trafficking protein particle complex 4
TRIM32 tripartite motif containing 32
USP22 ubiquitin specific peptidase 22
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)