BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-A68065211_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BGN biglycan
BTG3 BTG family, member 3
CBS cystathionine-beta-synthase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
FBXO11 F-box protein 11
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
HIST1H2AE histone cluster 1, H2ae
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITGA8 integrin, alpha 8
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LMO4 LIM domain only 4
LTBP1 latent transforming growth factor beta binding protein 1
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCQ protein kinase C, theta
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SOCS2 suppressor of cytokine signaling 2
SULF1 sulfatase 1
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TSPYL5 TSPY-like 5
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APMAP adipocyte plasma membrane associated protein
ARF4 ADP-ribosylation factor 4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
B3GNT1
BMI1 BMI1 proto-oncogene, polycomb ring finger
C20ORF24 chromosome 20 open reading frame 24
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHSY1 chondroitin sulfate synthase 1
CLTC clathrin, heavy chain (Hc)
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CST3 cystatin C
CTSH cathepsin H
CYTL1 cytokine-like 1
DCK deoxycytidine kinase
DUSP4 dual specificity phosphatase 4
DYNLT3 dynein, light chain, Tctex-type 3
ECI2 enoyl-CoA delta isomerase 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERBB3 erb-b2 receptor tyrosine kinase 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FASTKD5 FAST kinase domains 5
FGF13 fibroblast growth factor 13
FLNB filamin B, beta
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS7 growth arrest-specific 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXA10 homeobox A10
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIAA0907 KIAA0907
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LGALS1 lectin, galactoside-binding, soluble, 1
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
NISCH nischarin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
PROM1 prominin 1
PRSS23 protease, serine, 23
PTTG1 pituitary tumor-transforming 1
QDPR quinoid dihydropteridine reductase
RACGAP1 Rac GTPase activating protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS11 ribosomal protein S11
S100A4 S100 calcium binding protein A4
SEPHS1 selenophosphate synthetase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM9SF2 transmembrane 9 superfamily member 2
TMEM2 transmembrane protein 2
TMX4 thioredoxin-related transmembrane protein 4
TRAPPC3 trafficking protein particle complex 3
USP22 ubiquitin specific peptidase 22
VCAN versican
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)