BRD-A62809825_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-A62809825_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL8B ADP-ribosylation factor-like 8B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CHMP2B charged multivesicular body protein 2B
CLC Charcot-Leyden crystal galectin
COPA coatomer protein complex, subunit alpha
CREB3L2 cAMP responsive element binding protein 3-like 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
EREG epiregulin
FBN2 fibrillin 2
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1A interleukin 1, alpha
KDM5A lysine (K)-specific demethylase 5A
KRT6B keratin 6B, type II
LMO4 LIM domain only 4
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
NUCB2 nucleobindin 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PDLIM5 PDZ and LIM domain 5
PEA15 phosphoprotein enriched in astrocytes 15
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTN pleiotrophin
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TRIB3 tribbles pseudokinase 3
UBQLN2 ubiquilin 2
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APLP2 amyloid beta (A4) precursor-like protein 2
APOA2 apolipoprotein A-II
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BIN1 bridging integrator 1
CCNG1 cyclin G1
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CTSV cathepsin V
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX3 glutathione peroxidase 3
H3F3B H3 histone, family 3B (H3.3B)
HMGN3 high mobility group nucleosomal binding domain 3
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KRT19 keratin 19, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEFTY1 left-right determination factor 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MCM5 minichromosome maintenance complex component 5
MET MET proto-oncogene, receptor tyrosine kinase
MFAP3L microfibrillar-associated protein 3-like
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PODXL podocalyxin-like
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
TYMS thymidylate synthetase