BRD-A62025033_temsirolimus [CI779]_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-A62025033_temsirolimus [CI779]_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
FOLR1 folate receptor 1 (adult)
GPNMB glycoprotein (transmembrane) nmb
HOXD1 homeobox D1
INHBE inhibin, beta E
KRT19 keratin 19, type I
NMU neuromedin U
ORC1 origin recognition complex, subunit 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
QPCT glutaminyl-peptide cyclotransferase
RECQL RecQ helicase-like
RTN2 reticulon 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
CA2 carbonic anhydrase II
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CHERP calcium homeostasis endoplasmic reticulum protein
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
FAM35A family with sequence similarity 35, member A
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
KCTD12 potassium channel tetramerization domain containing 12
MARCKS myristoylated alanine-rich protein kinase C substrate
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTDSS1 phosphatidylserine synthase 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SAC3D1 SAC3 domain containing 1
SFRP4 secreted frizzled-related protein 4
SPARCL1 SPARC-like 1 (hevin)
ST7 suppression of tumorigenicity 7
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble