BRD-A60245366_AS-601245_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-A60245366_AS-601245_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AQP9 aquaporin 9
ARG2 arginase 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCL2A1 BCL2-related protein A1
CAPG capping protein (actin filament), gelsolin-like
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD1E CD1e molecule
CD48 CD48 molecule
CD52 CD52 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD9 CD9 molecule
CDC42 cell division cycle 42
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CLDN5 claudin 5
CLU clusterin
COASY CoA synthase
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CST3 cystatin C
CTSB cathepsin B
CTSH cathepsin H
CTSL cathepsin L
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
EGR1 early growth response 1
EML3 echinoderm microtubule associated protein like 3
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPM6A glycoprotein M6A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HACD3 3-hydroxyacyl-CoA dehydratase 3
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOMER1 homer scaffolding protein 1
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IGFBP3 insulin-like growth factor binding protein 3
IL1RN interleukin 1 receptor antagonist
IL7R interleukin 7 receptor
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LPL lipoprotein lipase
LRP12 low density lipoprotein receptor-related protein 12
LTBP3 latent transforming growth factor beta binding protein 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCOLN1 mucolipin 1
METRN meteorin, glial cell differentiation regulator
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRN1 neuritin 1
PCDH9 protocadherin 9
PDE8B phosphodiesterase 8B
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHACTR1 phosphatase and actin regulator 1
PI3 peptidase inhibitor 3, skin-derived
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PSAP prosaposin
RAD23B RAD23 homolog B (S. cerevisiae)
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPRR1B small proline-rich protein 1B
SRSF6 serine/arginine-rich splicing factor 6
STEAP1 six transmembrane epithelial antigen of the prostate 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
UBE2C ubiquitin-conjugating enzyme E2C
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WASF3 WAS protein family, member 3
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ARMT1 acidic residue methyltransferase 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C21ORF59 chromosome 21 open reading frame 59
CASP8AP2 caspase 8 associated protein 2
CCNA2 cyclin A2
CDCA4 cell division cycle associated 4
CDK4 cyclin-dependent kinase 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
JADE2 jade family PHD finger 2
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMI N-myc (and STAT) interactor
PAPOLA poly(A) polymerase alpha
PBX1 pre-B-cell leukemia homeobox 1
PDGFD platelet derived growth factor D
PHIP pleckstrin homology domain interacting protein
PTP4A1 protein tyrosine phosphatase type IVA, member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
USP18 ubiquitin specific peptidase 18
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein