BRD-A60245366_AS-601245_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-A60245366_AS-601245_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNN3 calponin 3, acidic
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
ENO2 enolase 2 (gamma, neuronal)
FAM63A family with sequence similarity 63, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
IDO1 indoleamine 2,3-dioxygenase 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MICALL1 MICAL-like 1
NAMPT nicotinamide phosphoribosyltransferase
NDRG2 NDRG family member 2
NMU neuromedin U
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NXT2 nuclear transport factor 2-like export factor 2
OLFML2A olfactomedin-like 2A
PDZK1IP1 PDZK1 interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PTN pleiotrophin
RAD23B RAD23 homolog B (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSX1 synovial sarcoma, X breakpoint 1
TBX3 T-box 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
VEGFA vascular endothelial growth factor A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ASPN asporin
ASRGL1 asparaginase like 1
BGN biglycan
C7 complement component 7
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD93 CD93 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP3 dual specificity phosphatase 3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FGFR2 fibroblast growth factor receptor 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HBB hemoglobin, beta
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
INSR insulin receptor
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPO myeloperoxidase
MYH11 myosin, heavy chain 11, smooth muscle
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PLAGL1 pleiomorphic adenoma gene-like 1
PLN phospholamban
PXDN peroxidasin
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STK10 serine/threonine kinase 10
STOM stomatin
THBD thrombomodulin
THBS1 thrombospondin 1
THBS4 thrombospondin 4
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TSPYL5 TSPY-like 5
VCAN versican
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB16 zinc finger and BTB domain containing 16