BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CALCA calcitonin-related polypeptide alpha
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLEC5A C-type lectin domain family 5, member A
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL11A1 collagen, type XI, alpha 1
COL5A1 collagen, type V, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTAG2 cancer/testis antigen 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
ENO1 enolase 1, (alpha)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GLTSCR2 glioma tumor suppressor candidate region gene 2
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LOC399491
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAGEA6 melanoma antigen family A6
MAST4 microtubule associated serine/threonine kinase family member 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAM maltase-glucoamylase
MINK1 misshapen-like kinase 1
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
NRG1 neuregulin 1
NXF1 nuclear RNA export factor 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCBP2 poly(rC) binding protein 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIR pirin (iron-binding nuclear protein)
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
RBM6 RNA binding motif protein 6
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
RPL10 ribosomal protein L10
RUNX3 runt-related transcription factor 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD5 SET domain containing 5
SIK3 SIK family kinase 3
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TRA2B transformer 2 beta homolog (Drosophila)
TSPYL2 TSPY-like 2
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
YEATS2 YEATS domain containing 2
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ACPP acid phosphatase, prostate
ACTA1 actin, alpha 1, skeletal muscle
ADCY1 adenylate cyclase 1 (brain)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ARHGAP29 Rho GTPase activating protein 29
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATMIN ATM interactor
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
B3GNT1
BHLHE41 basic helix-loop-helix family, member e41
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA2 cyclin A2
CD47 CD47 molecule
CDC20 cell division cycle 20
CPNE3 copine III
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DES desmin
DHCR24 24-dehydrocholesterol reductase
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F3 coagulation factor III (thromboplastin, tissue factor)
FANCF Fanconi anemia, complementation group F
FHL1 four and a half LIM domains 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GATA2 GATA binding protein 2
GBAS glioblastoma amplified sequence
GHR growth hormone receptor
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPER1 G protein-coupled estrogen receptor 1
GRHL2 grainyhead-like 2 (Drosophila)
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS1 insulin receptor substrate 1
JAG1 jagged 1
KLHL41 kelch-like family member 41
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LRRC17 leucine rich repeat containing 17
LRRC41 leucine rich repeat containing 41
LYPLA1 lysophospholipase I
MB myoglobin
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGST2 microsomal glutathione S-transferase 2
MRPL15 mitochondrial ribosomal protein L15
MRPL17 mitochondrial ribosomal protein L17
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL1 myosin, light chain 1, alkali; skeletal, fast
NEB nebulin
NKX3-1 NK3 homeobox 1
NOTCH2 notch 2
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
OPN3 opsin 3
OXTR oxytocin receptor
PEX11A peroxisomal biogenesis factor 11 alpha
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLN phospholamban
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPA2 pyrophosphatase (inorganic) 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PSD3 pleckstrin and Sec7 domain containing 3
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB2A RAB2A, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SLC25A46 solute carrier family 25, member 46
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLN sarcolipin
SPDEF SAM pointed domain containing ETS transcription factor
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TPM1 tropomyosin 1 (alpha)
TRAPPC4 trafficking protein particle complex 4
TRIB1 tribbles pseudokinase 1
TUBG1 tubulin, gamma 1
ZCCHC24 zinc finger, CCHC domain containing 24