BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
CALML3 calmodulin-like 3
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FZD10 frizzled class receptor 10
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDUA iduronidase, alpha-L-
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IL32 interleukin 32
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1M metallothionein 1M
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OXSR1 oxidative stress responsive 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RHCG Rh family, C glycoprotein
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERTAD2 SERTA domain containing 2
SFN stratifin
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPEN spen family transcriptional repressor
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP63 tumor protein p63
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADA adenosine deaminase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK2 AHNAK nucleoprotein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APMAP adipocyte plasma membrane associated protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CDA cytidine deaminase
CDC25B cell division cycle 25B
CENPA centromere protein A
CHRDL1 chordin-like 1
CTSC cathepsin C
CTSH cathepsin H
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL3 dihydropyrimidinase-like 3
ECD ecdysoneless homolog (Drosophila)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM208A family with sequence similarity 208, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
GPX3 glutathione peroxidase 3
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXA11 homeobox A11
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IL13RA2 interleukin 13 receptor, alpha 2
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
MFAP4 microfibrillar-associated protein 4
MRPS16 mitochondrial ribosomal protein S16
NCAM1 neural cell adhesion molecule 1
NPY neuropeptide Y
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
SEPT7 septin 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX11 SRY (sex determining region Y)-box 11
SPDL1 spindle apparatus coiled-coil protein 1
SRPX sushi-repeat containing protein, X-linked
SUB1 SUB1 homolog (S. cerevisiae)
TSPAN8 tetraspanin 8
VCAN versican