BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BEX4 brain expressed, X-linked 4
BMP7 bone morphogenetic protein 7
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CERK ceramide kinase
CRISP3 cysteine-rich secretory protein 3
DDIT4 DNA-damage-inducible transcript 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM46A family with sequence similarity 46, member A
FGG fibrinogen gamma chain
GAGE3 G antigen 3
HMOX1 heme oxygenase 1
KIAA0226L KIAA0226-like
LRRC15 leucine rich repeat containing 15
MTSS1 metastasis suppressor 1
NCOA3 nuclear receptor coactivator 3
PBX3 pre-B-cell leukemia homeobox 3
PIR pirin (iron-binding nuclear protein)
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK3 SIK family kinase 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
TYMP thymidine phosphorylase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
ARMT1 acidic residue methyltransferase 1
BAD BCL2-associated agonist of cell death
C1QBP complement component 1, q subcomponent binding protein
CALD1 caldesmon 1
CANT1 calcium activated nucleotidase 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBX3 chromobox homolog 3
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNG1 cyclin G1
CD320 CD320 molecule
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COX11 COX11 cytochrome c oxidase copper chaperone
CRYZ crystallin, zeta (quinone reductase)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDB2 damage-specific DNA binding protein 2, 48kDa
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHB4 EPH receptor B4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GPX1 glutathione peroxidase 1
HLTF helicase-like transcription factor
HOPX HOP homeobox
HOXA10 homeobox A10
IFT57 intraflagellar transport 57
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
KIAA0101 KIAA0101
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LAMC2 laminin, gamma 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
LOXL1 lysyl oxidase-like 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM6 minichromosome maintenance complex component 6
MDFIC MyoD family inhibitor domain containing
MLPH melanophilin
MRPS30 mitochondrial ribosomal protein S30
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NFIB nuclear factor I/B
NPY neuropeptide Y
NRP1 neuropilin 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLS1 plastin 1
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A46 solute carrier family 25, member 46
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
STOM stomatin
TARP TCR gamma alternate reading frame protein
TGM2 transglutaminase 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP6 thyroid hormone receptor interactor 6
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
WWTR1 WW domain containing transcription regulator 1