BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

172 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CTSB cathepsin B
CTSL cathepsin L
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FAM171A1 family with sequence similarity 171, member A1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
JAG1 jagged 1
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KYNU kynureninase
LRP10 low density lipoprotein receptor-related protein 10
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PMP22 peripheral myelin protein 22
RAP1GAP RAP1 GTPase activating protein
RPS11 ribosomal protein S11
S100A9 S100 calcium binding protein A9
SDC3 syndecan 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AGR2 anterior gradient 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD24 CD24 molecule
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
COX17 COX17 cytochrome c oxidase copper chaperone
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FEN1 flap structure-specific endonuclease 1
FLNB filamin B, beta
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H4C histone cluster 1, H4c
HLTF helicase-like transcription factor
HMGB2 high mobility group box 2
HOXC6 homeobox C6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MREG melanoregulin
MRPL42 mitochondrial ribosomal protein L42
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OLFML3 olfactomedin-like 3
PCNA proliferating cell nuclear antigen
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS23 protease, serine, 23
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB25 RAB25, member RAS oncogene family
RBBP8 retinoblastoma binding protein 8
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRI sorcin
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM106C transmembrane protein 106C
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUSC3 tumor suppressor candidate 3
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZNF22 zinc finger protein 22