BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
FADS1 fatty acid desaturase 1
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GLA galactosidase, alpha
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
LOXL2 lysyl oxidase-like 2
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIR pirin (iron-binding nuclear protein)
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC63 SEC63 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBD thrombomodulin
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTN1 actinin, alpha 1
AGTR1 angiotensin II receptor, type 1
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNF cyclin F
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPA centromere protein A
COA3 cytochrome c oxidase assembly factor 3
CTSC cathepsin C
DUSP6 dual specificity phosphatase 6
ERBB2 erb-b2 receptor tyrosine kinase 2
FEN1 flap structure-specific endonuclease 1
FXYD2 FXYD domain containing ion transport regulator 2
GRB14 growth factor receptor-bound protein 14
GSPT1 G1 to S phase transition 1
H2AFZ H2A histone family, member Z
HIST1H2BD histone cluster 1, H2bd
HOXA10 homeobox A10
HOXA5 homeobox A5
JADE2 jade family PHD finger 2
LAMB1 laminin, beta 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MET MET proto-oncogene, receptor tyrosine kinase
MRPL17 mitochondrial ribosomal protein L17
MRPL3 mitochondrial ribosomal protein L3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR2F6 nuclear receptor subfamily 2, group F, member 6
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
QPCT glutaminyl-peptide cyclotransferase
RBM47 RNA binding motif protein 47
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SMS spermine synthase
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIAP1 TP53 regulated inhibitor of apoptosis 1
ZDHHC11 zinc finger, DHHC-type containing 11