BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

300 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AIM2 absent in melanoma 2
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLIP1 CAP-GLY domain containing linker protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSB cathepsin B
CTSL cathepsin L
CTTN cortactin
CYB5R1 cytochrome b5 reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DST dystonin
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLG filaggrin
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GABARAPL1 GABA(A) receptor-associated protein like 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LCN2 lipocalin 2
LIN37 lin-37 DREAM MuvB core complex component
LPIN1 lipin 1
LYPD3 LY6/PLAUR domain containing 3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7D1 MAP7 domain containing 1
MIR22HG MIR22 host gene
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
PDLIM4 PDZ and LIM domain 4
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
PNOC prepronociceptin
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
QPCT glutaminyl-peptide cyclotransferase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALGDS ral guanine nucleotide dissociation stimulator
RHOF ras homolog family member F (in filopodia)
RHOQ ras homolog family member Q
RNF19B ring finger protein 19B
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMOX spermine oxidase
SPAG9 sperm associated antigen 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR2B small proline-rich protein 2B
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SYNM synemin, intermediate filament protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF20 transmembrane 4 L six family member 20
TP63 tumor protein p63
TPD52L1 tumor protein D52-like 1
TRIM29 tripartite motif containing 29
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBE2H ubiquitin-conjugating enzyme E2H
UPP1 uridine phosphorylase 1
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
ANOS1 anosmin 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ATF1 activating transcription factor 1
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BPHL biphenyl hydrolase-like (serine hydrolase)
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
CA1 carbonic anhydrase I
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAT catalase
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNG1 cyclin G1
CD302 CD302 molecule
CD69 CD69 molecule
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK2 checkpoint kinase 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DEK DEK proto-oncogene
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELAVL1 ELAV like RNA binding protein 1
ELP5 elongator acetyltransferase complex subunit 5
FABP1 fatty acid binding protein 1, liver
FAM13A family with sequence similarity 13, member A
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FGFR4 fibroblast growth factor receptor 4
FSTL1 follistatin-like 1
FUS FUS RNA binding protein
GATA2 GATA binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRB14 growth factor receptor-bound protein 14
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HMGN3 high mobility group nucleosomal binding domain 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEX3D mex-3 RNA binding family member D
MRPL42 mitochondrial ribosomal protein L42
MSH6 mutS homolog 6
MSL1 male-specific lethal 1 homolog (Drosophila)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
PRPF19 pre-mRNA processing factor 19
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTTG1 pituitary tumor-transforming 1
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RNF130 ring finger protein 130
RPL31 ribosomal protein L31
RPS21 ribosomal protein S21
RSL1D1 ribosomal L1 domain containing 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCP2 sterol carrier protein 2
SELENBP1 selenium binding protein 1
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SERBP1 SERPINE1 mRNA binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRPF small nuclear ribonucleoprotein polypeptide F
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF1 serine/arginine-rich splicing factor 1
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI2 tissue factor pathway inhibitor 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM109 transmembrane protein 109
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOX thymocyte selection-associated high mobility group box
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)