BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADM adrenomedullin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CSRP1 cysteine and glycine-rich protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CYBRD1 cytochrome b reductase 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGR1 early growth response 1
FAM198B family with sequence similarity 198, member B
FOS FBJ murine osteosarcoma viral oncogene homolog
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
JAG1 jagged 1
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLVAP plasmalemma vesicle associated protein
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SFN stratifin
SRGN serglycin
TNNT1 troponin T type 1 (skeletal, slow)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
AIM1 absent in melanoma 1
APLP2 amyloid beta (A4) precursor-like protein 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CLTC clathrin, heavy chain (Hc)
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
DLD dihydrolipoamide dehydrogenase
DNM1L dynamin 1-like
DUSP10 dual specificity phosphatase 10
EED embryonic ectoderm development
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FBXO28 F-box protein 28
G0S2 G0/G1 switch 2
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IPO5 importin 5
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF1BP KIF1 binding protein
KRT7 keratin 7, type II
MET MET proto-oncogene, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGES prostaglandin E synthase
PURA purine-rich element binding protein A
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
S100A11 S100 calcium binding protein A11
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEPT9 septin 9
SET SET nuclear proto-oncogene
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SRSF6 serine/arginine-rich splicing factor 6
STEAP3 STEAP family member 3, metalloreductase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TMX4 thioredoxin-related transmembrane protein 4
TSC22D1 TSC22 domain family, member 1
VCAN versican
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBTB18 zinc finger and BTB domain containing 18