BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP1 aquaporin 1 (Colton blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALCA calcitonin-related polypeptide alpha
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
ELOVL5 ELOVL fatty acid elongase 5
EZR ezrin
FAM46A family with sequence similarity 46, member A
FGFR1 fibroblast growth factor receptor 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAL galanin/GMAP prepropeptide
GAREM GRB2 associated, regulator of MAPK1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHMBP2 immunoglobulin mu binding protein 2
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP3 nuclear receptor interacting protein 3
NUPL1 nucleoporin like 1
OLFML2A olfactomedin-like 2A
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK1 proprotein convertase subtilisin/kexin type 1
PER1 period circadian clock 1
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RNF167 ring finger protein 167
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SST somatostatin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TBX2 T-box 2
TFF3 trefoil factor 3 (intestinal)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABHD10 abhydrolase domain containing 10
ACOT9 acyl-CoA thioesterase 9
ADD3 adducin 3 (gamma)
AFP alpha-fetoprotein
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF1 activating transcription factor 1
BEX1 brain expressed, X-linked 1
C2CD5 C2 calcium-dependent domain containing 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CMC4 C-x(9)-C motif containing 4
COG2 component of oligomeric golgi complex 2
COL1A2 collagen, type I, alpha 2
CTSB cathepsin B
DCK deoxycytidine kinase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DERA deoxyribose-phosphate aldolase (putative)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EBAG9 estrogen receptor binding site associated, antigen, 9
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERLIN1 ER lipid raft associated 1
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GSPT2 G1 to S phase transition 2
HIST1H4C histone cluster 1, H4c
HOXA10 homeobox A10
HOXA5 homeobox A5
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP4 insulin-like growth factor binding protein 4
IL27RA interleukin 27 receptor, alpha
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JADE2 jade family PHD finger 2
KLHL9 kelch-like family member 9
LTBP1 latent transforming growth factor beta binding protein 1
MANSC1 MANSC domain containing 1
MEIS2 Meis homeobox 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MGST2 microsomal glutathione S-transferase 2
MRPL15 mitochondrial ribosomal protein L15
MRPL34 mitochondrial ribosomal protein L34
MSH2 mutS homolog 2
MSRB2 methionine sulfoxide reductase B2
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
NREP neuronal regeneration related protein
OLFM4 olfactomedin 4
PAK1IP1 PAK1 interacting protein 1
PCNA proliferating cell nuclear antigen
PCTP phosphatidylcholine transfer protein
PDGFC platelet derived growth factor C
PGRMC2 progesterone receptor membrane component 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX4 peroxiredoxin 4
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SEPHS1 selenophosphate synthetase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TRAPPC4 trafficking protein particle complex 4
TRIM14 tripartite motif containing 14
TSPAN4 tetraspanin 4
TST thiosulfate sulfurtransferase (rhodanese)
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UMPS uridine monophosphate synthetase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VCAN versican
WDR3 WD repeat domain 3
ZNF185 zinc finger protein 185 (LIM domain)