BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
CCNL1 cyclin L1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CLGN calmegin
COL11A1 collagen, type XI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRISP3 cysteine-rich secretory protein 3
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTTN cortactin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FAM69A family with sequence similarity 69, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GARS glycyl-tRNA synthetase
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPG2 heparan sulfate proteoglycan 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INSR insulin receptor
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KTN1 kinectin 1 (kinesin receptor)
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MFSD10 major facilitator superfamily domain containing 10
MXI1 MAX interactor 1, dimerization protein
MYO1B myosin IB
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NPC1 Niemann-Pick disease, type C1
NUCB1 nucleobindin 1
OLFML2A olfactomedin-like 2A
P4HB prolyl 4-hydroxylase, beta polypeptide
PAM peptidylglycine alpha-amidating monooxygenase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLVAP plasmalemma vesicle associated protein
PNKP polynucleotide kinase 3'-phosphatase
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRRC2C proline-rich coiled-coil 2C
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RSRC2 arginine/serine-rich coiled-coil 2
SARS seryl-tRNA synthetase
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNX11 sorting nexin 11
STC1 stanniocalcin 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WBP4 WW domain binding protein 4
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADI1 acireductone dioxygenase 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMD1 adenosylmethionine decarboxylase 1
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATF1 activating transcription factor 1
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
C1RL complement component 1, r subcomponent-like
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNG1 cyclin G1
CD24 CD24 molecule
CDC14B cell division cycle 14B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
COPS4 COP9 signalosome subunit 4
COX11 COX11 cytochrome c oxidase copper chaperone
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DLD dihydrolipoamide dehydrogenase
DUSP4 dual specificity phosphatase 4
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPN2 epsin 2
FABP7 fatty acid binding protein 7, brain
FANCF Fanconi anemia, complementation group F
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GRB14 growth factor receptor-bound protein 14
GRSF1 G-rich RNA sequence binding factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOPX HOP homeobox
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA14 heat shock 70kDa protein 14
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
KIAA0391 KIAA0391
KLF10 Kruppel-like factor 10
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM1 LSM1, U6 small nuclear RNA associated
LY75 lymphocyte antigen 75
LYPLA1 lysophospholipase I
LYZ lysozyme
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKSL1 MARCKS-like 1
MB myoglobin
MMP7 matrix metallopeptidase 7
MPHOSPH9 M-phase phosphoprotein 9
MRPL15 mitochondrial ribosomal protein L15
MSH6 mutS homolog 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAP1L1 nucleosome assembly protein 1-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PBX1 pre-B-cell leukemia homeobox 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLN phospholamban
PON2 paraoxonase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCB protein kinase C, beta
PROM1 prominin 1
PRPF4B pre-mRNA processing factor 4B
PRR7 proline rich 7 (synaptic)
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS2 regulator of G-protein signaling 2
RNASET2 ribonuclease T2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SEPHS1 selenophosphate synthetase 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A46 solute carrier family 25, member 46
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC44A4 solute carrier family 44, member 4
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRP72 signal recognition particle 72kDa
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUB1 SUB1 homolog (S. cerevisiae)
TFAM transcription factor A, mitochondrial
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOX3 TOX high mobility group box family member 3
TRAPPC4 trafficking protein particle complex 4
TSKU tsukushi, small leucine rich proteoglycan
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
UBE2N ubiquitin-conjugating enzyme E2N
UPK1B uroplakin 1B
VCAN versican
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1