BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-A58924247_2-[(chloroacetyl)(4-methoxyphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ARC activity-regulated cytoskeleton-associated protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC5 chloride intracellular channel 5
CRABP2 cellular retinoic acid binding protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD10 frizzled class receptor 10
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAST4 microtubule associated serine/threonine kinase family member 4
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH3 notch 3
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEA15 phosphoprotein enriched in astrocytes 15
PI3 peptidase inhibitor 3, skin-derived
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SQSTM1 sequestosome 1
SST somatostatin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG6 adhesion G protein-coupled receptor G6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AMD1 adenosylmethionine decarboxylase 1
AURKA aurora kinase A
B3GNT1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BUB3 BUB3 mitotic checkpoint protein
C12ORF29 chromosome 12 open reading frame 29
CANT1 calcium activated nucleotidase 1
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
ELOVL6 ELOVL fatty acid elongase 6
ERBB2 erb-b2 receptor tyrosine kinase 2
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
FZD7 frizzled class receptor 7
GPX2 glutathione peroxidase 2
GRB14 growth factor receptor-bound protein 14
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
HOXC6 homeobox C6
IFRD2 interferon-related developmental regulator 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LPL lipoprotein lipase
MSH6 mutS homolog 6
NPY neuropeptide Y
OSBPL8 oxysterol binding protein-like 8
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPARG peroxisome proliferator-activated receptor gamma
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRPF4 pre-mRNA processing factor 4
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SFRP1 secreted frizzled-related protein 1
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
VCAN versican