BRD-A58767537_afatinib_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-A58767537_afatinib_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNG2 cyclin G2
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DDIT4 DNA-damage-inducible transcript 4
EHF ets homologous factor
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FZD7 frizzled class receptor 7
HIST1H2AC histone cluster 1, H2ac
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1 insulin-like growth factor 1 (somatomedin C)
KIAA0355 KIAA0355
MDFIC MyoD family inhibitor domain containing
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NMU neuromedin U
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PROM1 prominin 1
PSAP prosaposin
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SLC38A1 solute carrier family 38, member 1
SLPI secretory leukocyte peptidase inhibitor
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SYNM synemin, intermediate filament protein
TBC1D31 TBC1 domain family, member 31
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMD1 adenosylmethionine decarboxylase 1
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CDC25A cell division cycle 25A
CHN1 chimerin 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
FOLR1 folate receptor 1 (adult)
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF10 Kruppel-like factor 10
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR6 lysophosphatidic acid receptor 6
MAK16 MAK16 homolog (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MSMB microseminoprotein, beta-
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NPTX2 neuronal pentraxin II
NUP98 nucleoporin 98kDa
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
TFF1 trefoil factor 1
TXNDC9 thioredoxin domain containing 9
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon