BRD-A58767537_afatinib_SKBR3_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-A58767537_afatinib_SKBR3_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
DDIT4 DNA-damage-inducible transcript 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GPM6B glycoprotein M6B
HMG20B high mobility group 20B
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0355 KIAA0355
KIAA1033 KIAA1033
KRT15 keratin 15, type I
LITAF lipopolysaccharide-induced TNF factor
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
MSLN mesothelin
NEBL nebulette
PEBP1 phosphatidylethanolamine binding protein 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
SMC1A structural maintenance of chromosomes 1A
TFF3 trefoil factor 3 (intestinal)
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
BGN biglycan
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CHN2 chimerin 2
CXCL8 chemokine (C-X-C motif) ligand 8
DLX2 distal-less homeobox 2
DUSP7 dual specificity phosphatase 7
EGLN3 egl-9 family hypoxia-inducible factor 3
ENOPH1 enolase-phosphatase 1
GJA1 gap junction protein, alpha 1, 43kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
MSMO1 methylsterol monooxygenase 1
MXRA7 matrix-remodelling associated 7
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NKX3-1 NK3 homeobox 1
PRPF4 pre-mRNA processing factor 4
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STK39 serine threonine kinase 39
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4