BRD-A58767537_afatinib_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

337 genes differentially expressed following the BRD-A58767537_afatinib_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANXA4 annexin A4
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD14 CD14 molecule
CD47 CD47 molecule
CDR2L cerebellar degeneration-related protein 2-like
CFB complement factor B
CFD complement factor D (adipsin)
CLDN7 claudin 7
CLIC5 chloride intracellular channel 5
CLU clusterin
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTSD cathepsin D
CTSS cathepsin S
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DNASE2 deoxyribonuclease II, lysosomal
DSP desmoplakin
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP3 fatty acid binding protein 3, muscle and heart
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRN granulin
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
ITGB4 integrin, beta 4
JAM2 junctional adhesion molecule 2
JUP junction plakoglobin
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC16A leucine rich repeat containing 16A
MAN1A1 mannosidase, alpha, class 1A, member 1
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NOV nephroblastoma overexpressed
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAM peptidylglycine alpha-amidating monooxygenase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PI3 peptidase inhibitor 3, skin-derived
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNXB tenascin XB
TP53TG1 TP53 target 1 (non-protein coding)
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBXN4 UBX domain protein 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV5 ets variant 5
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NRG1 neuregulin 1
NT5E 5'-nucleotidase, ecto (CD73)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
THBS1 thrombospondin 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPRKB TP53RK binding protein
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
USP1 ubiquitin specific peptidase 1
VIM vimentin
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein