BRD-A58767537_afatinib_LNCAP_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

297 genes differentially expressed following the BRD-A58767537_afatinib_LNCAP_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG2 adhesion G protein-coupled receptor G2
AIF1 allograft inflammatory factor 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF4 activating transcription factor 4
BGN biglycan
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C14ORF1 chromosome 14 open reading frame 1
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHN2 chimerin 2
CLN3 ceroid-lipofuscinosis, neuronal 3
COL1A1 collagen, type I, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSA cathepsin A
CTSD cathepsin D
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EBP emopamil binding protein (sterol isomerase)
ENO2 enolase 2 (gamma, neuronal)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EVI2A ecotropic viral integration site 2A
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FAM46A family with sequence similarity 46, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FNDC3B fibronectin type III domain containing 3B
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNPDA1 glucosamine-6-phosphate deaminase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITM2A integral membrane protein 2A
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC16A leucine rich repeat containing 16A
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY96 lymphocyte antigen 96
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MOSPD1 motile sperm domain containing 1
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MTSS1 metastasis suppressor 1
MVP major vault protein
MYO1D myosin ID
NAGK N-acetylglucosamine kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2B olfactomedin-like 2B
OLFML3 olfactomedin-like 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDZK1IP1 PDZK1 interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
QPRT quinolinate phosphoribosyltransferase
RAB29 RAB29, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RHOBTB3 Rho-related BTB domain containing 3
RHOQ ras homolog family member Q
RIN3 Ras and Rab interactor 3
RIT1 Ras-like without CAAX 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGC Ras-related GTP binding C
S100A14 S100 calcium binding protein A14
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STAB1 stabilin 1
STX3 syntaxin 3
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TM6SF1 transmembrane 6 superfamily member 1
TMEM135 transmembrane protein 135
TMEM2 transmembrane protein 2
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TWF2 twinfilin actin binding protein 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
VAT1 vesicle amine transport 1
WBP5 WW domain binding protein 5
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
YPEL5 yippee-like 5 (Drosophila)
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AHCY adenosylhomocysteinase
AHR aryl hydrocarbon receptor
AKAP1 A kinase (PRKA) anchor protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCHE butyrylcholinesterase
BOP1 block of proliferation 1
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CALD1 caldesmon 1
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CHPT1 choline phosphotransferase 1
CKLF chemokine-like factor
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPNE3 copine III
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTBP2 C-terminal binding protein 2
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHFR dihydrofolate reductase
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DPH2 DPH2 homolog (S. cerevisiae)
EIF3K eukaryotic translation initiation factor 3, subunit K
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
ETV1 ets variant 1
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FXYD6 FXYD domain containing ion transport regulator 6
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP4 GTP binding protein 4
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HELLS helicase, lymphoid-specific
HOMER2 homer scaffolding protein 2
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IPO4 importin 4
IPO5 importin 5
KCTD12 potassium channel tetramerization domain containing 12
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LAMA3 laminin, alpha 3
LDHB lactate dehydrogenase B
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MME membrane metallo-endopeptidase
MRPL12 mitochondrial ribosomal protein L12
MRPS2 mitochondrial ribosomal protein S2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NDNF neuron-derived neurotrophic factor
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NREP neuronal regeneration related protein
ODC1 ornithine decarboxylase 1
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PCNA proliferating cell nuclear antigen
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRDX4 peroxiredoxin 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF4 pre-mRNA processing factor 4
PUF60 poly-U binding splicing factor 60KDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
RUVBL1 RuvB-like AAA ATPase 1
SAMHD1 SAM domain and HD domain 1
SEPHS1 selenophosphate synthetase 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TCF4 transcription factor 4
TFAM transcription factor A, mitochondrial
TFB2M transcription factor B2, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TMPO thymopoietin
TMSB15A thymosin beta 15a
TRIP13 thyroid hormone receptor interactor 13
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
UNG uracil-DNA glycosylase
VIM vimentin
ZNF239 zinc finger protein 239