BRD-A58767537_afatinib_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-A58767537_afatinib_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASNS asparagine synthetase (glutamine-hydrolyzing)
C10ORF10 chromosome 10 open reading frame 10
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPHB2 EPH receptor B2
FBLN1 fibulin 1
FBLN2 fibulin 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FRZB frizzled-related protein
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2A integral membrane protein 2A
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
METTL7A methyltransferase like 7A
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIL3 nuclear factor, interleukin 3 regulated
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PLS3 plastin 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBP1 retinol binding protein 1, cellular
RELN reelin
RSRP1 arginine/serine-rich protein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFF3 trefoil factor 3 (intestinal)
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
CCNE2 cyclin E2
CDCP1 CUB domain containing protein 1
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
CXCL8 chemokine (C-X-C motif) ligand 8
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IER3 immediate early response 3
IL1B interleukin 1, beta
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR2F6 nuclear receptor subfamily 2, group F, member 6
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
PRKCD protein kinase C, delta
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP1 topoisomerase (DNA) I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VCAN versican