BRD-A56592690_PX12_VCAP_6.0_h_30.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

368 genes differentially expressed following the BRD-A56592690_PX12_VCAP_6.0_h_30.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
AHCYL2 adenosylhomocysteinase-like 2
AIF1 allograft inflammatory factor 1
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1R complement component 1, r subcomponent
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD163 CD163 molecule
CD300A CD300a molecule
CD69 CD69 molecule
CD83 CD83 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CH25H cholesterol 25-hydroxylase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHMP4A charged multivesicular body protein 4A
CLEC7A C-type lectin domain family 7, member A
CLIC4 chloride intracellular channel 4
COBL cordon-bleu WH2 repeat protein
CSF1 colony stimulating factor 1 (macrophage)
CSRNP2 cysteine-serine-rich nuclear protein 2
CST1 cystatin SN
CTSE cathepsin E
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYB5R2 cytochrome b5 reductase 2
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP6 dual specificity phosphatase 6
EBI3 Epstein-Barr virus induced 3
EFNA1 ephrin-A1
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGD6 FYVE, RhoGEF and PH domain containing 6
FILIP1L filamin A interacting protein 1-like
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GCH1 GTP cyclohydrolase 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
HCP5 HLA complex P5 (non-protein coding)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL15RA interleukin 15 receptor, alpha
IL32 interleukin 32
ILK integrin-linked kinase
INSM1 insulinoma-associated 1
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JADE2 jade family PHD finger 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
LIF leukemia inhibitory factor
LSR lipolysis stimulated lipoprotein receptor
LTF lactotransferrin
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPT microtubule-associated protein tau
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEOX2 mesenchyme homeobox 2
MIA melanoma inhibitory activity
MICALL2 MICAL-like 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MOXD1 monooxygenase, DBH-like 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTMR11 myotubularin related protein 11
MVP major vault protein
NCF2 neutrophil cytosolic factor 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFE2L3 nuclear factor, erythroid 2-like 3
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NNMT nicotinamide N-methyltransferase
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PAM peptidylglycine alpha-amidating monooxygenase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCOLCE procollagen C-endopeptidase enhancer
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCARD PYD and CARD domain containing
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS3 regulator of G-protein signaling 3
RHOG ras homolog family member G
RIPK2 receptor-interacting serine-threonine kinase 2
RND1 Rho family GTPase 1
RND3 Rho family GTPase 3
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUNX3 runt-related transcription factor 3
S100B S100 calcium binding protein B
SCG2 secretogranin II
SDC4 syndecan 4
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX11 sorting nexin 11
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
TAGLN2 transgelin 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TESC tescalcin
TF transferrin
TFE3 transcription factor binding to IGHM enhancer 3
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM2 transmembrane protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNIP1 TNFAIP3 interacting protein 1
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRAF1 TNF receptor-associated factor 1
TRAFD1 TRAF-type zinc finger domain containing 1
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TYMP thymidine phosphorylase
VAMP5 vesicle-associated membrane protein 5
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM10 ADAM metallopeptidase domain 10
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
AKAP1 A kinase (PRKA) anchor protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
B3GNT1
BCHE butyrylcholinesterase
C2CD5 C2 calcium-dependent domain containing 5
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPU centromere protein U
CLGN calmegin
CRISP3 cysteine-rich secretory protein 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DCK deoxycytidine kinase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EBAG9 estrogen receptor binding site associated, antigen, 9
EIF4E eukaryotic translation initiation factor 4E
EREG epiregulin
FAM35A family with sequence similarity 35, member A
FANCI Fanconi anemia, complementation group I
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLOD4 glyoxalase domain containing 4
GLUD1 glutamate dehydrogenase 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA8A golgin A8 family, member A
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPNMB glycoprotein (transmembrane) nmb
GRWD1 glutamate-rich WD repeat containing 1
HLTF helicase-like transcription factor
HMGB2 high mobility group box 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP1 insulin-like growth factor binding protein 1
IPO7 importin 7
KIF11 kinesin family member 11
KRT19 keratin 19, type I
LBR lamin B receptor
LDHB lactate dehydrogenase B
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBNL1 muscleblind-like splicing regulator 1
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MTDH metadherin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDRG3 NDRG family member 3
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NMT1 N-myristoyltransferase 1
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDGFC platelet derived growth factor C
PI3 peptidase inhibitor 3, skin-derived
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB2A RAB2A, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
REEP5 receptor accessory protein 5
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RRAGD Ras-related GTP binding D
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCAMP1 secretory carrier membrane protein 1
SDC1 syndecan 1
SEH1L SEH1-like (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SESN1 sestrin 1
SHCBP1 SHC SH2-domain binding protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SORD sorbitol dehydrogenase
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TEX30 testis expressed 30
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMX4 thioredoxin-related transmembrane protein 4
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TTC19 tetratricopeptide repeat domain 19
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBXN8 UBX domain protein 8
VRK1 vaccinia related kinase 1
WAPAL wings apart-like homolog (Drosophila)
WT1 Wilms tumor 1