BRD-A56020723_CA-074-Me_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-A56020723_CA-074-Me_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CALML5 calmodulin-like 5
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPC1 glypican 1
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GSR glutathione reductase
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KRT10 keratin 10, type I
KRT16 keratin 16, type I
KYNU kynureninase
LCN2 lipocalin 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP3L microfibrillar-associated protein 3-like
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAMPT nicotinamide phosphoribosyltransferase
NLGN4X neuroligin 4, X-linked
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
P3H2 prolyl 3-hydroxylase 2
PEG3 paternally expressed 3
PGD phosphogluconate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHCG Rh family, C glycoprotein
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SFN stratifin
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORD sorbitol dehydrogenase
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
STAR steroidogenic acute regulatory protein
THBD thrombomodulin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB1 transducer of ERBB2, 1
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CAPG capping protein (actin filament), gelsolin-like
CD9 CD9 molecule
CLDN3 claudin 3
CXCL10 chemokine (C-X-C motif) ligand 10
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM3C family with sequence similarity 3, member C
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IGHM immunoglobulin heavy constant mu
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MOXD1 monooxygenase, DBH-like 1
MYB v-myb avian myeloblastosis viral oncogene homolog
OXTR oxytocin receptor
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCP4 Purkinje cell protein 4
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POSTN periostin, osteoblast specific factor
PRSS2 protease, serine, 2 (trypsin 2)
RGS2 regulator of G-protein signaling 2
SDC4 syndecan 4
THBS1 thrombospondin 1
TMSB15B thymosin beta 15B
TUBA1A tubulin, alpha 1a
VTCN1 V-set domain containing T cell activation inhibitor 1
WEE1 WEE1 G2 checkpoint kinase