BRD-A56020723_CA-074-Me_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A56020723_CA-074-Me_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
ANXA1 annexin A1
ANXA2 annexin A2
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CDH3 cadherin 3, type 1, P-cadherin (placental)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLU clusterin
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELOVL5 ELOVL fatty acid elongase 5
EPHA4 EPH receptor A4
FTL ferritin, light polypeptide
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GCLM glutamate-cysteine ligase, modifier subunit
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR2 lysophosphatidic acid receptor 2
LXN latexin
LY96 lymphocyte antigen 96
LYPD1 LY6/PLAUR domain containing 1
MAOB monoamine oxidase B
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
NMU neuromedin U
NPTX2 neuronal pentraxin II
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLIN2 perilipin 2
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RNF167 ring finger protein 167
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TKT transketolase
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VLDLR very low density lipoprotein receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADGRG6 adhesion G protein-coupled receptor G6
BMP2 bone morphogenetic protein 2
C1ORF116 chromosome 1 open reading frame 116
CANT1 calcium activated nucleotidase 1
CAPN3 calpain 3, (p94)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FST follistatin
FUCA1 fucosidase, alpha-L- 1, tissue
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
ISG15 ISG15 ubiquitin-like modifier
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAGEA12 melanoma antigen family A12
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPS16 mitochondrial ribosomal protein S16
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
PEG10 paternally expressed 10
PLP1 proteolipid protein 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SEPT11 septin 11
SKAP2 src kinase associated phosphoprotein 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
TACC1 transforming, acidic coiled-coil containing protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17