BRD-A56020723_CA-074-Me_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-A56020723_CA-074-Me_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AOX1 aldehyde oxidase 1
AQP9 aquaporin 9
BCL6 B-cell CLL/lymphoma 6
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C5AR1 complement component 5a receptor 1
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD163 CD163 molecule
CD8A CD8a molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CST7 cystatin F (leukocystatin)
CTSL cathepsin L
CYBB cytochrome b-245, beta polypeptide
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCLK1 doublecortin-like kinase 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP6 dual specificity phosphatase 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF13 fibroblast growth factor 13
FPR1 formyl peptide receptor 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSAP gamma-secretase activating protein
GSR glutathione reductase
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
KYNU kynureninase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
RBP4 retinol binding protein 4, plasma
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
TXNRD1 thioredoxin reductase 1
TYROBP TYRO protein tyrosine kinase binding protein
UGDH UDP-glucose 6-dehydrogenase
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTA2 actin, alpha 2, smooth muscle, aorta
AREG amphiregulin
BHLHE40 basic helix-loop-helix family, member e40
CCDC92 coiled-coil domain containing 92
CCL2 chemokine (C-C motif) ligand 2
CDC42 cell division cycle 42
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
CTSV cathepsin V
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDAH2 dimethylarginine dimethylaminohydrolase 2
DHCR7 7-dehydrocholesterol reductase
EPHA3 EPH receptor A3
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GOLM1 golgi membrane protein 1
HLA-B major histocompatibility complex, class I, B
HOXA10 homeobox A10
HOXA5 homeobox A5
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LRRN3 leucine rich repeat neuronal 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NREP neuronal regeneration related protein
OPTN optineurin
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PFKP phosphofructokinase, platelet
PRSS2 protease, serine, 2 (trypsin 2)
RAB25 RAB25, member RAS oncogene family
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SH3YL1 SH3 and SYLF domain containing 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TMSB15A thymosin beta 15a
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)