BRD-A56020723_CA-074-Me_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-A56020723_CA-074-Me_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
ADGRG1 adhesion G protein-coupled receptor G1
ADM adrenomedullin
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
BAG3 BCL2-associated athanogene 3
BMP4 bone morphogenetic protein 4
CA12 carbonic anhydrase XII
CLU clusterin
CST1 cystatin SN
CTSL cathepsin L
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FGL2 fibrinogen-like 2
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FZD10 frizzled class receptor 10
FZD7 frizzled class receptor 7
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
ITM2A integral membrane protein 2A
KEAP1 kelch-like ECH-associated protein 1
KYNU kynureninase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PMP22 peripheral myelin protein 22
PRKCQ protein kinase C, theta
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
REEP1 receptor accessory protein 1
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TDP2 tyrosyl-DNA phosphodiesterase 2
THBD thrombomodulin
TM4SF1 transmembrane 4 L six family member 1
TPBG trophoblast glycoprotein
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
DUSP10 dual specificity phosphatase 10
ERBB3 erb-b2 receptor tyrosine kinase 3
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FAM3C family with sequence similarity 3, member C
FMO3 flavin containing monooxygenase 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX1 glutathione peroxidase 1
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ISG15 ISG15 ubiquitin-like modifier
KIAA0922 KIAA0922
LPIN2 lipin 2
LUM lumican
MT1E metallothionein 1E
MX1 MX dynamin-like GTPase 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
RAB4A RAB4A, member RAS oncogene family
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC6 zinc finger, DHHC-type containing 6