BRD-A56020723_CA-074-Me_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-A56020723_CA-074-Me_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRG1 adhesion G protein-coupled receptor G1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
AMPD3 adenosine monophosphate deaminase 3
ASTN2 astrotactin 2
ATF3 activating transcription factor 3
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BLVRB biliverdin reductase B
C1S complement component 1, s subcomponent
C20ORF24 chromosome 20 open reading frame 24
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLGN calmegin
CLU clusterin
COL16A1 collagen, type XVI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTSB cathepsin B
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP1 dual specificity phosphatase 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FADS1 fatty acid desaturase 1
FAS Fas cell surface death receptor
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GPC1 glypican 1
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
IGFBP6 insulin-like growth factor binding protein 6
IL6 interleukin 6
ISLR immunoglobulin superfamily containing leucine-rich repeat
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KLK10 kallikrein-related peptidase 10
KLK6 kallikrein-related peptidase 6
LDLR low density lipoprotein receptor
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP2K3 mitogen-activated protein kinase kinase 3
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MAX MYC associated factor X
MCUR1 mitochondrial calcium uniporter regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PITRM1 pitrilysin metallopeptidase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PLIN3 perilipin 3
PTX3 pentraxin 3, long
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A6 solute carrier family 38, member 6
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRGN serglycin
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAR steroidogenic acute regulatory protein
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBX3 T-box 3
TGFBR3 transforming growth factor, beta receptor III
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM16 tripartite motif containing 16
TSPAN7 tetraspanin 7
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VLDLR very low density lipoprotein receptor
WT1 Wilms tumor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADGRG6 adhesion G protein-coupled receptor G6
AIM1 absent in melanoma 1
ANXA4 annexin A4
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATP11B ATPase, class VI, type 11B
BAD BCL2-associated agonist of cell death
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPNS1 calpain, small subunit 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC85B coiled-coil domain containing 85B
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CETN2 centrin, EF-hand protein, 2
CHRDL1 chordin-like 1
CIRBP cold inducible RNA binding protein
CST3 cystatin C
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EID1 EP300 interacting inhibitor of differentiation 1
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
FABP7 fatty acid binding protein 7, brain
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FIBP fibroblast growth factor (acidic) intracellular binding protein
FST follistatin
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GPM6A glycoprotein M6A
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IRS2 insulin receptor substrate 2
KRT18 keratin 18, type I
LEPR leptin receptor
LUM lumican
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METRN meteorin, glial cell differentiation regulator
MTCL1 microtubule crosslinking factor 1
MYH10 myosin, heavy chain 10, non-muscle
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
PCDH9 protocadherin 9
PDZK1 PDZ domain containing 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLS1 plastin 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRDX2 peroxiredoxin 2
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOX11 SRY (sex determining region Y)-box 11
SOX2 SRY (sex determining region Y)-box 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SV2A synaptic vesicle glycoprotein 2A
TBCB tubulin folding cofactor B
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TNIK TRAF2 and NCK interacting kinase
TPM1 tropomyosin 1 (alpha)
TRMT5 tRNA methyltransferase 5
VCAN versican