BRD-A54927599_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-A54927599_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
CALML5 calmodulin-like 5
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLTB clathrin, light chain B
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
INHBB inhibin, beta B
ISG20 interferon stimulated exonuclease gene 20kDa
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MFSD10 major facilitator superfamily domain containing 10
MICALL1 MICAL-like 1
MMP7 matrix metallopeptidase 7
NPC1 Niemann-Pick disease, type C1
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLIN3 perilipin 3
PMEPA1 prostate transmembrane protein, androgen induced 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PYGB phosphorylase, glycogen; brain
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCG5 secretogranin V
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPRR1A small proline-rich protein 1A
SPTBN1 spectrin, beta, non-erythrocytic 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPO translocator protein (18kDa)
TXNRD1 thioredoxin reductase 1
VCL vinculin
WDR1 WD repeat domain 1
ZYX zyxin

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASPN asporin
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
CD14 CD14 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CLCA1 chloride channel accessory 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSF1R colony stimulating factor 1 receptor
CXADR coxsackie virus and adenovirus receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP1 fatty acid binding protein 1, liver
FCGBP Fc fragment of IgG binding protein
GRN granulin
H3F3B H3 histone, family 3B (H3.3B)
HBB hemoglobin, beta
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MAGEA3 melanoma antigen family A3
METTL7A methyltransferase like 7A
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP85 nucleoporin 85kDa
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDGFD platelet derived growth factor D
PSPH phosphoserine phosphatase
REG3A regenerating islet-derived 3 alpha
RPS11 ribosomal protein S11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SRGN serglycin
SYT1 synaptotagmin I
TF transferrin
TFRC transferrin receptor
TMEM97 transmembrane protein 97
TNS3 tensin 3
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)